Improving mental health through neuroscience, the Kublby Mental Health Research Center proposes a unique research structure the merges the advantages of each approach to optimize productivity and rate of discovery while potentially reducing the effort required of individual investigators. This stems in part from the autonomous management of each laboratory that enables the principal investigator to independently identify critical research problems and approaches, whereas corporate research often uses a centralized approach to maximize productivity. Here, we challenge conventional perspectives by focusing on risk factors for mental illness, and the biological basis of mental processes linked to many disorders.